Which antidote is used for acetaminophen overdose?

• A. N-acetylcysteine
• B. Activated charcoal
• C. Atropine
• D. Naloxone

Answer: (A)

N-acetylcysteine is the antidote for acetaminophen overdose because it replenishes depleted glutathione stores in the liver, allowing the harmful metabolite NAPQI to be detoxified and safely eliminated. By supplying a sulfur-containing donor, NAC supports conjugation of NAPQI with glutathione, reducing liver cell injury and improving outcomes. It’s most effective when started early, ideally within about eight to ten hours after ingestion, though it can still help later on. It can be given orally or intravenously depending on the clinical situation.

Activated charcoal can be useful soon after ingestion to limit absorption, but it is not an antidote. Atropine treats anticholinergic effects, and naloxone reverses opioid toxicity; neither addresses acetaminophen poisoning.